基本信息
CAS号
136572-09-3
EINECS号
——
分子式
C33H39ClN4O6
分子量
623.139
别名
盐酸依立替康三水合物, L-(+)-N-[4-[[(2,4-二氨基-6-蝶啶基)甲氨基]苯甲三水合物, 三水盐酸伊立替康, 盐酸三水伊立替康三水合物, 伊立替康盐酸盐三水合物, 盐酸伊立替康三水化合物, L-(+)-N-[4-[[(2,4-二氨基-6-蝶啶基)甲氨基]苯甲三水合物
英文名称
Irinotecan hydrochloride trihydrate
英文别名
(+)-7-Ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate, monohydrochloride, trihydrate, Camptosar, Irinotecan HCl trihydrate, (1,4'-Bipiperidine)-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-, (1,4'-bipiperidine)-1'-carboxylicacid,4,11-diethyl-3,4,12,14-tetrahydro-4-hyd monohydrochloride, trihydrate, roxy-3,14-dioxo-1h-pyrano(3',4',6,7)indolizino(1,2-b)quinolin-9-ylester,mono, trihydrate,(s)-hydrochlorid trihydrate, irinotecan monohydrochloride trihydrate, [1,4'-bipiperidine]-1'-carboxylic acid (s)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano, [3',4',6,7]indolizino[1,2-b]quinolin-9-yl ester, hcl trihydrate, (s)-[1,4'-bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano, [3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate, irinotecanhydrochloridetrihydrate(cpt-11), (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl [1,4'-bipiperidine]-1'-carboxylate trihydrate hydrochloride, (+)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, monohydrochloride, trihydrate, (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate, (S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate, [1,4'-Bipiperidine]-1'-carboxylic acid,4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride,trihydrate, (S)-, [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
物化性质
熔点
250-256℃ (dec.)
沸点
产品用途
主要用于治疗消化系统肿瘤如胃癌、结肠癌、直肠癌、肺癌等，也用于治疗白血病、葡萄胎和绒毛膜上皮癌。伊立替康是一种经过化学结构修饰的天然喜树碱的衍生物。它是疗效确切、毒副作用较小的新型抗癌药物，主要用于治疗肺癌、结直肠癌、胃癌、子宫癌、卵巢癌等癌症
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